Last season’s top two meet at the Etihad with City boasting a perfect record so far this term. Arsenal, have won three of four, with their only blemish that 1-1 draw at home to Brighton.
The Gunners confirmed the extent of Martin Odegaard’s ankle injury this week with the Norway international expected to be out until mid-November.
The club captain will miss some huge games in that period starting with the visit to the Etihad on Sunday where Arteta will again be without Mikel Merino.
The Spain international suffered a shoulder injury in his first training session with the club and is not expected to be back until next month.
Declan Rice is available once again after serving his suspension and is expected to join Thomas Partey and Jorginho in midfield.
Kai Havertz dropped into a deeper midfield role on Thursday night against Atalanta with Gabriel Jesus leading the line in Bergamo but the Germany international should return to his more familiar role up top against the champions.
Raheem Sterling made his debut off the bench in the `1-0 win over Tottenham last week and will be pushing for a starting role against the side he scored 91 goals for.
Bukayo Saka meanwhile came off with cramp against Spurs but was back in the side against Atalanta, playing 73 minutes before being replaced by Sterling.
Manchester City could also have a problem in midfield with Kevin de Bruyne injured midweek ahead of Sunday’s clash.
The Belgium international was forced off at half-time in Wednesday’s goalless draw with Inter Milan with a suspected hamstring injury.
While de Bruyne was expected to miss today’s game, Pep Guardiola hinted he could still feature.
‘He feels a little better today… Tomorrow we train and we will see. He could be [involved],’ Guardiola told a press conference on Friday.
Wednesday night marked Rodri’s first start of the season with Phil Foden coming off the bench in the second-half.